Pathophysiology- gasrtic acid stimulation on PUD,GERD,GASTRITIS Essay

Pathophysiology- gasrtic acid stimulation on PUD,GERD,GASTRITIS - Essay ExampleThere are 4 main phases in the process of gastric acid production and these include basal phase which is constant acid release into the stomach. The cephalic phase involves the training for eating and acid secretion is triggered by impulses from higher CNS structures through CN X. Acid secretion in the gastric phase is due to distention of the tummy and the intestinal phase is stimulated by amino acids and intestinal distension (Malfertheiner, 2009).There are several disorders that can occur as a ensue of hypersacidity which include peptic ulcer disease, gastroesophageal reflux and gastritis. The acid accumulation in these cases is due to a series of aggressive factors such as alcohol, h. pylori and NSAIDs. For physical exertion in patients with hyperacid dyspepsia due to Helicobacter pylori there is an increase in gastrin production which stimulates the the parietal cells to produce HCl. Dietary fact ors and consumption of alcohol leads to stimulation of gastric mucosa leading to hypersecretion of acid from the parietal cells (Patel & Gyawali, 2012).Genetics have a role to play in the development of PUD, gastritis and GERD due to several reasons. Firstly, hyperacid dyspepsia can be a genetic condition whereby an individual naturally produces an elevated amount of acid therefore making him or her predisposed to developing the above mentioned conditions. another(prenominal) genetic conditions such as hyperpepsinogemenia play a role in the development of peptic ulcer disease. Genetic defects of lower esophageal sphincter cash in ones chips also predispose an individual to GERD. Autoimmune disorders, cancers and allergic reactions increase an individuals chances of developing peptic ulcers or gastritis (Patel & Gyawali,